CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis.

Naema Nayyar Magali A de Sauvage Jane Chuprin Emily M Sullivan Mohini Singh Consuelo Torrini Britney S Zhang Sushobhana Bandyopadhyay Keith A Daniels Christopher Alvarez-Breckenridge Ashish Dahal Michael A Brehm Priscilla Kaliopi Brastianos

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our results highlight the distinct properties of intracranial and extracranial tumors and support clinical investigation of combination CDK4/6 and PD-1 inhibition in patients with brain metastases.

Keyphrases

brain metastases
small cell lung cancer
cell cycle
optic nerve
internal carotid artery
white matter
resting state
induced apoptosis
cell proliferation
mesenchymal stem cells
functional connectivity
bone marrow
endoplasmic reticulum stress
middle cerebral artery