Predictors of Preterm Neonatal Mortality in India and Pakistan: A Secondary Analysis of Data from PURPOSe Study.
Shiyam Sundar TikmaniSarah SaleemAfreen SadiaCarla M BannMuhammad Hayat BozdarJamal RazaSangappa M DhadedShivaprasad S GoudarGuruparasad GowdarHaleema YasminElizabeth M McClureRobert L GoldenbergPublished in: Global pediatric health (2024)
Objective. To create a prediction model for preterm neonatal mortality. Methods. A secondary analysis was conducted using data from a prospective cohort study, the Project to Understand and Research Preterm Pregnancy Outcome South Asia. The Cox proportional hazard model was used and adjusted hazard ratios (AHR) with 95% confidence intervals (95% CI) were reported. Results. Overall, 3446 preterm neonates were included. The mean age of preterm neonates was 0.65 (1.25) hours and 52% were female. The preterm neonatal mortality rate was 23.3%. The maternal factors predicting preterm neonatal death was any antepartum hemorrhage, AHR 1.99 (1.60-2.47), while neonatal predictors were preterm who received positive pressure ventilation AHR 1.30 (1.08-1.57), temperature <35.5°C AHR 1.18 (1.00-1.39), and congenital malformations AHR 3.31 (2.64-4.16). Conclusion. This study identified key maternal and neonatal predictors of preterm neonatal mortality, emphasizing the need for targeted interventions and collaborative public health efforts to address disparities and regional variations.
Keyphrases
- low birth weight
- preterm birth
- gestational age
- preterm infants
- birth weight
- public health
- cardiovascular events
- quality improvement
- healthcare
- pregnancy outcomes
- cardiovascular disease
- physical activity
- coronary artery disease
- pregnant women
- intensive care unit
- drug delivery
- big data
- data analysis
- deep learning
- mechanical ventilation
- affordable care act