Fgf9 promotes incisor dental epithelial stem cell survival and enamel formation.

Lingyun TangMingmei ChenMin WuHui LiangHaoyang GeYan MaYan ShenShunyuan LuChunling ShenHongxin ZhangChenping ZhangZhu-Gang Wang

Published in: Stem cell research & therapy (2024)

Our study demonstrates that Fgf9 is essential for DESC survival and enamel formation. Fgf9 performs as a dual-directional regulator of the dental enamel epithelium, not only inhibiting DESC differentiation into ameloblasts to preserve the stemness of DESC, but also promoting ameloblast differentiation through epithelial-mesenchymal interactions.

Keyphrases

stem cells
oral health
bone marrow
epithelial mesenchymal transition
signaling pathway
free survival
cancer stem cells