The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells.

Kimberly C OlneyDavid B NyerDaniel A VargasMelissa A Wilson SayresKarmella A Haynes

Published in: BMC systems biology (2018)

Our results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription.

Keyphrases

transcription factor
breast cancer cells
dna methylation
genome wide
dna binding
dendritic cells
gene expression
genome wide identification
binding protein
protein protein
amino acid
heat shock
genome wide analysis
oxidative stress