Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early- to Mid-Stage Parkinson's Disease Modification Trials.

Nirosen VijiaratnamChristine GirgesDilan AthaudaAlexa KingGrace AuldRachel McComishKashfia ChowdhurySimon SkeneKate MaclaganKallol Ray ChaudhuriVincenzo LibriJohn DicksonThomas Foltynie

Published in: Movement disorders clinical practice (2024)

These data suggest that DAT SBR could be a useful biomarker in disease-modifying trials, but a focus on anterior striatal subregions and incorporating disease duration into analyses may improve its utility.

Keyphrases

parkinson disease
functional connectivity
electronic health record
uric acid
metabolic syndrome
transcription factor
data analysis
deep learning
artificial intelligence