Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators, and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues.
R Arruda-VasconcelosV M Chiarelli-NetoL M LouzadaE AveiroE G Alves-SilvaA de-Jesus-SoaresC C R FerrazJosé Flávio Affonso de AlmeidaMarina Angélica Marciano da SilvaV G A PecorariBrenda Paula Figueiredo de Almeida GomesPublished in: International endodontic journal (2023)
Teeth with symptomatic irreversible pulpitis present higher levels of culturable bacteria, endotoxins, TNF-α and substance P than those with vital normal pulp tissues. On the other hand, the levels of IL-1β were similar in teeth from both groups suggesting reduced implications of this inflammatory mediator in the early stages of infection.