SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers.
Stefano PorruMaria Grazia Lourdes MonacoGianluca SpiteriAngela CartaMaria Diletta PezzaniGian Luca SalvagnoDavide GibelliniEvelina TacconelliIlaria Dalla VecchiaEmma SalaEmanuele SansoneGiuseppe DePalmaCarlo BonfantiMassimo LombardoLuigina TerlenghiEnrico PiraIhab MansourMaurizio CoggiolaCatalina CiocanAlessandro GodonoAdonina TardónMarta-Maria Rodriguez-SuarezGuillermo Fernandez-TardónFrancisco-Jose Jimeno-DemuthRafael-Vicente Castro-DelgadoTania Iglesias CaboMaria Luisa ScapellatoFilippo LivieroAngelo MorettoPaola MasonSofia PavanelloAnna VolpinLuigi VimercatiStefano TermiteLuigi de MariaStefania SponselliPasquale StefanizziAntonio CaputiFabrizio Maria GobbaAlberto ModeneseLoretta CasolariDenise GaraviniCristiana D'EliaStefania MarianiFrancesca Larese FilonLuca CegolonCorrado NegroFederico RoncheseFrancesca RuiPaola De MichieliNicola MurgiaMarco Dell'OmoGiacomo MuziTiziana FiordiAngela GambelungheIlenia FollettiDana MatesVioleta Claudia CalotaAndra NeamtuOvidiu PersecaCatalin Alexandru StaicuAngelica VoinoiuEleonóra FabiánováJana BérešováZora Kľocová AdamčákováRoman NedelaAnna LesnakovaJana HolčíkováPaolo BoffettaMahsa AbediniGiorgia DitanoShuffield Seyram AsafoGiovanni VisciFrancesco Saverio ViolanteCarlotta ZunarelliGiuseppe VerlatoPublished in: Vaccines (2022)
The inverse correlation of antibody titer with the risk of breakthrough infection supports the evidence that vaccination plays a primary role in infection prevention, especially in health workers. Cellular immunity, previous clinical conditions, and vaccination timing should be further investigated.