Epidemiology and complications of late-onset sepsis: an Italian area-based study.
Alberto BerardiFrancesca SforzaLorenza BaroniCaterina SpadaSimone AmbrettiGiacomo BiasucciSerenella BolognesiMariagrazia CaprettiEdoardo CarrettoMatilde CicciaMarcello LanariMaria Federica PednaVittoria RizzoClaudia VenturelliCrisoula TziallaLaura LucaccioniMaria Letizia Bacchi ReggianiPublished in: PloS one (2019)
This study provides the first Italian data regarding late-onset sepsis (LOS) in all gestational age groups. Compared to full-term neonates, very high rates of LOS and mortality occurred in neonates with a lower birth weight and gestational age. Group B streptococcus was the leading cause of meningitis. Excluding CoNS, the predominant pathogens were Escherichia coli and Staphylococcus aureus. Neonates with hospital-acquired LOS had a worse outcome. Antibiotic associations, recommended for empirical treatment of hospital- or community-acquired LOS, were adequate.
Keyphrases
- gestational age
- late onset
- birth weight
- preterm birth
- low birth weight
- early onset
- escherichia coli
- staphylococcus aureus
- healthcare
- biofilm formation
- risk factors
- intensive care unit
- acute kidney injury
- septic shock
- acute care
- mental health
- adverse drug
- weight gain
- candida albicans
- electronic health record
- gram negative
- physical activity
- cystic fibrosis
- big data
- body mass index
- klebsiella pneumoniae
- deep learning
- cardiovascular disease
- multidrug resistant
- machine learning
- cerebrospinal fluid