Maximizing treatment opportunities: assessing protocol waivers' impact on safety and outcome in the Drug Rediscovery Protocol.
J Maxime van Berge HenegouwenLaurien J ZeverijnBirgit S GeurtsLouisa R HoesHanneke van der WijngaartVincent van den NoortAlwin D R HuitemaFilip Yves Francine De VosKatrien GrünbergHaiko J BloemendalHenk M W VerheulEmile E VoestAndré B P van KuilenburgPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Safety and clinical benefit were preserved in patients for whom a waiver was granted. These data support a more personalized approach in assessing eligibility criteria, especially in trials with widely used and approved drugs accruing patients without other treatment options.