Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification.

Qianru YuMaxin ZhangYuetan ChenXiaolong ChenSanyuan ShiKang SunRan YeYuan ZhengYang ChenYuhong XuJinliang Peng

Published in: International journal of nanomedicine (2020)

These results indicated that pEGFRvIII-CAR@SNPG1/800 can effectively achieve T-cell transient CAR modification, thereby demonstrating considerable potential in CAR-T cancer therapy.

Keyphrases

cancer therapy
cerebral ischemia
drug delivery
copy number
genome wide
subarachnoid hemorrhage
gene expression
genome wide identification