Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.

Sven ReinhardtFlorian SchuckNicolai StoyeTobias HartmannMarcus O W GrimmGert PflugfelderKristina Endres

Published in: Cellular and molecular life sciences : CMLS (2019)

Our results characterize TBX2 as a repressor of ADAM10 gene expression and suggest that this regulatory interaction is conserved across tissues and species.

Keyphrases

gene expression
transcription factor
dna methylation
cognitive decline
oxidative stress
risk assessment
mild cognitive impairment