Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease.

Ruben J ColmanYi-Ting TsaiKimberly JacksonBrendan M BoyleJoshua D NoeJeffrey S HyamsGeert R A M D'HaensJohan van LimbergenMichael J RosenLee A DensonPhillip Minar

Published in: Inflammatory bowel diseases (2022)

This study establishes cut points in neutrophil stool and blood biomarkers for both biochemical remission and therapeutic trough levels following induction therapy. Further studies that evaluate pharmacodynamic biomarker targets for endoscopic and histologic healing are warranted.

Keyphrases

ulcerative colitis
ultrasound guided
disease activity
stem cells
rheumatoid arthritis
emergency department
systemic lupus erythematosus
cell therapy
drug induced