Chaenomelis fructus inhibits osteoclast differentiation by suppressing NFATc1 expression and prevents ovariectomy-induced osteoporosis.

Minsun KimHo-Seok KimJae-Hyun KimEun-Young KimBina LeeSung Yub LeeJae-Yun JunMin Beom KimYoungjoo SohnHyuk Sang Jung

Published in: BMC complementary medicine and therapies (2020)

Based on the results of in vivo and in vitro experiments, CF inhibited the RANKL-induced osteoclasts differentiation and its function and effectively ameliorated OVX-induced osteoporosis rats.

Keyphrases

high glucose
diabetic rats
bone loss
postmenopausal women
drug induced
cystic fibrosis
binding protein