5α-Hydroxycostic acid inhibits choroidal neovascularization in rats through a dual signalling pathway mediated by VEGF and angiopoietin 2.

Wulong LeiHuan XuHao YaoLanjiao LiMenglei WangXiyuan ZhouXueqin Liu

Published in: Molecular medicine (Cambridge, Mass.) (2023)

5α-Hydroxycostic acid can inhibit choroidal neovascularization by interfering with the VEGF- and Ang2/Tie2-related pathways, and it may be a good candidate drug for treating CNV.

Keyphrases

vascular endothelial growth factor
optical coherence tomography
endothelial cells
diabetic retinopathy
age related macular degeneration
angiotensin ii
optic nerve
emergency department
electronic health record