Targeting TGFβ Pathway in Adult Granulosa Cell Tumor: Opening Pandora's Box?

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Adult granulosa cell tumor (AGCT) is a rare malignancy characterized by FOXL2 (C134W) mutation, an inherent component of the TGFβ pathway. Activin A, a TGFβ superfamily member, is a driver of this activity and is a potential target in AGCT.See related article by Tao et al., p. 5458.

Keyphrases

transforming growth factor
single cell
cell therapy
type diabetes
transcription factor
stem cells
epithelial mesenchymal transition
risk assessment
climate change