Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5.

Udayakumar KarunakaranSuma ElumalaiJun Sung MoonJae Han JeonNam Doo KimKeun Gyu ParkKyu Chang WonJaechan Leem In-Kyu Lee

Published in: Diabetes & metabolism journal (2019)

Myricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b.

Keyphrases

induced apoptosis
high glucose
endoplasmic reticulum stress
signaling pathway
endothelial cells
cell cycle
cell proliferation
oxidative stress
pi k akt
cell cycle arrest
tyrosine kinase
protein kinase
fluorescent probe
long non coding rna
living cells
drug induced
cell death
diabetic rats
aqueous solution