Recent advances in gene therapy for atrial fibrillation.
Shin YooGail Elizabeth GeistAnna PfennigerMarkus RottmannRishi AroraPublished in: Journal of cardiovascular electrophysiology (2021)
Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments for AF are suboptimal as they are not targeting the molecular mechanisms underlying AF. In this regard, gene therapy is emerging as a promising approach for mechanism-based treatment of AF. In this review, we summarize recent advances and challenges in gene therapy for this important cardiovascular disease.
Keyphrases
- atrial fibrillation
- gene therapy
- oral anticoagulants
- catheter ablation
- left atrial
- cardiovascular disease
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- type diabetes
- copy number
- gene expression
- dna methylation
- metabolic syndrome
- drug delivery
- cancer therapy
- acute coronary syndrome
- blood pressure
- combination therapy
- single molecule
- smoking cessation
- cardiovascular risk factors