Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment.
Natalie M NiessenPeter G GibsonKatherine J BainesDaniel BarkerIan A YangJohn W UphamPaul N ReynoldsSandra HodgeAlan L JamesChristine JenkinsMatthew J PetersGuy B MarksMelissa BaraketJodie L SimpsonMichael FrickerPublished in: Allergy (2021)
We demonstrate dysregulation of TNF markers, particularly in the airways, that relates to clinically important phenotypes of asthma including neutrophilic and severe asthma. Suppression of dysregulated TNF signalling by azithromycin could contribute to its therapeutic mechanism.