Login / Signup

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment.

Natalie M NiessenPeter G GibsonKatherine J BainesDaniel BarkerIan A YangJohn W UphamPaul N ReynoldsSandra HodgeAlan L JamesChristine JenkinsMatthew J PetersGuy B MarksMelissa BaraketJodie L SimpsonMichael Fricker
Published in: Allergy (2021)
We demonstrate dysregulation of TNF markers, particularly in the airways, that relates to clinically important phenotypes of asthma including neutrophilic and severe asthma. Suppression of dysregulated TNF signalling by azithromycin could contribute to its therapeutic mechanism.
Keyphrases
  • rheumatoid arthritis
  • cystic fibrosis
  • chronic obstructive pulmonary disease
  • mycobacterium tuberculosis
  • lung function
  • pulmonary tuberculosis