White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells.

Cheng-Chih HsiaoNina L FransenAletta M R van den BoschKim I M BrandwijkInge HuitingaJörg Hamann Joost J F M Smolders

Published in: European journal of immunology (2020)

Brain CD8+ CD69+ tissue-resident memory T (TRM ) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.

Keyphrases

multiple sclerosis
white matter
induced apoptosis
nk cells
cell cycle arrest
mass spectrometry
stem cells
patient safety
endoplasmic reticulum stress
single cell
bone marrow
oxidative stress
mesenchymal stem cells
cell proliferation
brain injury
blood brain barrier
subarachnoid hemorrhage