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Host IP 3 R channels are dispensable for rotavirus Ca 2+ signaling but critical for intercellular Ca 2+ waves that prime uninfected cells for rapid virus spread.

Jacob L PerryFrancesca J ScribanoJohn T GebertKristen A EngevikJenna M EllisJoseph M Hyser
Published in: mBio (2023)
signals from the ICWs may prime nearby uninfected cells to better support virus replication upon eventual infection. This "pre-emptive priming" of uninfected cells by exploiting host intercellular pathways in the vicinity of virus-infected cells represents a novel mechanism for viral reprogramming of the host to gain a replication advantage.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • hiv infected
  • endoplasmic reticulum stress
  • cell death