Sustained post-rituximab B cell depletion is common in ANCA-associated Vasculitis and affected by sex and renal function.
Frederica MesciaChiara SalvianiMattia TonoliStefania AffatatoDaniele MorattoMartina TedescoAlice GueriniAlessia GemmoMarta CamoniElisa DelbarbaRoberto ZubaniEmirena GarrafaMarco ChiariniGina GregoriniFrancesco ScolariFederico AlbericiPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
A subset of AAV patients develop sustained post-rituximab B cell depletion, which associates with reduced risk of flare and increased risk of serious infection in the long term. Preserved renal function and female sex are associated with faster B cell repopulation. These observations further highlight the need to personalize immunosuppression to improve clinical outcomes.