Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice.
Tyler S NelsonDiogo F S SantosPranav PrasoonMargaret GralinskiHeather N AllenBradley K TaylorPublished in: PNAS nexus (2023)
Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G-protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) or neuropeptide Y Y1 receptor (Y1R) activity, persist in the spinal cord dorsal horn (DH) for months, even after the resolution of normal pain thresholds. Here, we demonstrate that following recovery from surgical incision, a potent endogenous analgesic synergy between MOR and Y1R activity persists within DH interneurons to reduce the intensity and duration of latent postoperative hypersensitivity and ongoing pain. Failure of such endogenous GPCR signaling to maintain LS in remission may underlie the transition from acute to chronic pain states.
Keyphrases
- chronic pain
- pain management
- neuropathic pain
- spinal cord
- postoperative pain
- spinal cord injury
- drug induced
- patients undergoing
- metabolic syndrome
- anti inflammatory
- type diabetes
- binding protein
- respiratory failure
- high intensity
- extracorporeal membrane oxygenation
- systemic lupus erythematosus
- insulin resistance
- skeletal muscle