SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy.

Xin-Yu ZhaoShuang-Shuang LiYing-Xin HeLi-Jie YanFu LvQi-Meng LiangYu-Hui GanLi-Pei HanHong-de XuYong-Chun LiYuan-Yuan Qi

Published in: Annals of the rheumatic diseases (2023)

This study confirmed the renoprotective effect of SGLT2 inhibitors in lupus mice, providing more evidence for non-immunosuppressive therapies to improve renal function in classic autoimmune kidney diseases such as LN.

Keyphrases

oxidative stress
systemic lupus erythematosus
diabetic nephropathy
cell death
multiple sclerosis
endoplasmic reticulum stress
disease activity
type diabetes
rheumatoid arthritis
endothelial cells