Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease.

Martin KarlSolveig HasselwanderYawen ZhouGisela ReifenbergYong Ook KimKyoung-Sook ParkDirk A RidderXiaoyu WangEric SeidelNadine HövelmeyerBeate K StraubHuige LiDetlef SchuppanNing Xia

Published in: Hepatology (Baltimore, Md.) (2022)

B lymphocytes have both detrimental and protective effects in HFD-induced NAFLD. The lack of secreted pathogenic antibodies protects partially from NAFLD, whereas the presence of certain B cell subsets provides additional protection. IL-10-producing regulatory B cells may represent such a protective B cell subset.

Keyphrases

peripheral blood
mouse model
high glucose
high fat diet
diabetic rats
transcription factor
drug induced
adipose tissue
metabolic syndrome
liver fibrosis