Strain-level bacterial typing directly from patient samples using optical DNA mapping.
My NyblomAnna JohnningKarolin FrykholmMarie WrandeVilhelm MüllerGaurav GoyalMiriam RobertssonAlbertas DvirnasTsegaye SewunetSriram K KTobias AmbjörnssonChristian G GiskeLinus SandegrenErik KristianssonFredrik WesterlundPublished in: Communications medicine (2023)
The optical DNA mapping method is accurate and directly applicable to polymicrobial and clinical samples without cultivation. Hence, it has the potential to rapidly provide comprehensive diagnostics information, thereby optimizing early antibiotic treatment and opening up for future precision medicine management.