Role of proton pump inhibitors dosage and duration in Helicobacter pylori eradication treatment: Results from the European Registry on H. pylori management.
Manuel Pabón CarrascoAlma Keco-HuergaManuel Castro-FernándezIlaria Maria SaracinoGiulia FioriniDino VairaÁngeles Pérez-AísaBojan TepesLaimas JonaitisIrina VoynovanAlfredo J LucendoÁngel LanasSamuel J Martínez-DomínguezEnrique Alfaro AlmajanoLuis RodrigoLudmila VologzaninaNatasa Brglez JurecicMaja DenkovskiLuis BujandaRustam A AbdulkhakovJose M HuguetLuis Fernández-SalazarNoelia AlcaideBenito VelayosAiman Silkanovna SarsenbaevaOleg ZaytsevTatiana IlchishinaJesús BarrioIgor BakulinMonica PeronaSergey AlekseenkoMarco RomanoAntonietta Gerarda GravinaÓscar NúñezBlas José Gómez RodríguezDiego Ledro-CanoRinaldo PellicanoPavel BogomolovManuel Domínguez-CajalPedro AlmelaJudith Gomez-CamareroDmitry S BordinAntonio GasbarriniJuozas KupčinskasAnna Cano-CatalàLeticia MoreiraOlga P NyssenFrancis MégraudColm O'MorainFrancisco Javier García-Alonsonull nullPublished in: United European gastroenterology journal (2023)
We recommend, in first-line treatment, the use of high-dose PPIs in 14-day triple therapy and in 10-or 14-day quadruple concomitant therapy in first-line treatment, while standard-dose PPIs would be sufficient in 10-day bismuth quadruple therapies. On the other hand, in second-line treatment, high-dose PPIs would be more beneficial in 14-day triple therapy with levofloxacin and amoxicillin or in 10-day bismuth quadruple therapy either as a three-in-one single capsule or in the traditional scheme.