Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen.
Naofumi AmiokaChia-Hua WuHisashi Sawada (澤田悠)Sohei ItoAlex C PetteyCongqing WuJessica J MoorleghenDeborah A HowattGregory A GrafCraig W Vander KooiAlan DaughertyHong S Lu (吕红)Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)
The conserved sequences in either the loop or β-sheet region individually have no effect on AGT regulation, but the conserved sequences in both regions synergistically contribute to the secretion of AGT from hepatocytes.