Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes.

Shu-Bin FangHong-Yu ZhangAi-Yun JiangXing-Liang FanYong-Dong LinCheng-Lin LiCong WangXiang-Ci MengQing-Ling Fu

Published in: Stem cell research & therapy (2018)

iPSC-MSCs showed therapeutic potentials in neutrophilic airway inflammation through the regulation on Th17 cells, suggesting that the iPSC-MSCs could be applied in the therapy for the asthma patients with steroid-resistant neutrophilic airway inflammation.

Keyphrases

induced pluripotent stem cells
mesenchymal stem cells
umbilical cord
induced apoptosis
endothelial cells
cell cycle arrest
chronic obstructive pulmonary disease
signaling pathway
lung function
bone marrow
oxidative stress
cell death
cell proliferation
allergic rhinitis
pi k akt