The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury.

Meiling ZhangJia ZhuNannan WangWenpei LiuLihuan LuHongqiu PanXiaomin HeHonggang YiShao-Wen Tang

Published in: Journal of clinical pharmacy and therapeutics (2022)

Based on this 1:4 individual matched case-control study, SNP rs11660001 in the FECH gene may be associated with susceptibility to AT-DILI in Chinese female anti-TB treatment patients. Further studies in larger varied populations are needed to validate our findings.

Keyphrases

genome wide
mycobacterium tuberculosis
newly diagnosed
ejection fraction
copy number
risk assessment
prognostic factors
dna methylation
emergency department
patient reported outcomes
combination therapy
human immunodeficiency virus