AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer's Disease by Enhancing Autophagy.

Yang Deng Si-Yu WangQing-Guang WangZhao-Han XuQiang PengShuai-Yu ChenLin ZhuYing-Dong ZhangRui Duan

Published in: Journal of inflammation research (2023)

These findings suggest that regulation of autophagy is critical for inhibiting astrocyte neuroinflammatory responses and demonstrate a potential neuroprotective mechanism by which AVE 0991 could suppress neuroinflammatory responses by enhancing autophagy.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
traumatic brain injury
cerebral ischemia
lipopolysaccharide induced
cognitive impairment
risk assessment
inflammatory response
human health
blood brain barrier
climate change