Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes.

Mamta Amrute-NayakGloria PegoliTim HollerAlfredo Jesus Lopez-DavilaChiara LanzuoloArnab Nayak

Published in: Journal of cachexia, sarcopenia and muscle (2020)

The results show that the drugs critically alter SENP3-dependent synergistic action of histone-modifying enzymes in muscle cells. Collectively, we defined a unique epigenetic mechanism targeted by distinct chemotherapeutic drugs, triggering chemotherapy-induced cachexia.

Keyphrases

chemotherapy induced
dna methylation
induced apoptosis
cancer therapy
cell cycle arrest
gene expression
skeletal muscle
endoplasmic reticulum stress
squamous cell carcinoma
oxidative stress
drug delivery
signaling pathway
cell proliferation
radiation therapy
pi k akt