Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections.

Qiuji YeHassane BelabedYong WangZhifeng YuMurugesan PalaniappanJian-Yuan LiStacey A KalovidourisKevin R MacKenzieMingxing TengDamian W YoungYoshitaka Fujihara Martin M Matzuk

Published in: Andrology (2022)

With the ASMS/LC-MS/MS assay developed in this paper, we successfully discovered a PDCL2 ligand that warrants further development as a male contraceptive.

Keyphrases

high throughput
circulating tumor
small molecule
cell free
single molecule
nucleic acid
single cell