Frequency, entity and determinants of fatigue in Charcot-Marie-Tooth disease.
Marta BellofattoAlessandro BertiniIrene TramacereFiore ManganelliGian Maria FabriziAngelo SchenoneLucio SantoroTiziana CavallaroMarina GrandisStefano Carlo PrevitaliYuri FalzoneIsabella AllegriLuca PaduaCostanza PazzagliaDaniela CalabresePaola SaveriAldo QuattronePaola ValentinoStefano TozzaLuca GentileMassimo RussoAnna MazzeoGiuseppe VitaSylvie PiacentiniChiara PisciottaDavide Pareysonnull nullPublished in: European journal of neurology (2022)
Fatigue is a relevant symptom in CMT as 36% of our series had scores indicating abnormal fatigue. It correlated with disease severity but also with anxiety, depression, sleepiness and obesity, indicating different components in the generation of fatigue. CMT patients' management must include treatment of fatigue and of its different generators, including general distress, sleepiness and obesity.
Keyphrases
- sleep quality
- depressive symptoms
- metabolic syndrome
- insulin resistance
- weight loss
- physical activity
- type diabetes
- end stage renal disease
- obstructive sleep apnea
- newly diagnosed
- weight gain
- ejection fraction
- chronic kidney disease
- prognostic factors
- body mass index
- sleep apnea
- patient reported
- patient reported outcomes
- skeletal muscle
- positive airway pressure