IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review.
Justyna Szydlowska-GladyszAdrianna Edyta GoreckaJulia StepienIzabela RyszIwona Ben-SkowronekPublished in: International journal of molecular sciences (2024)
This study examines the impact of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2) on various aspects of children's health-from the realms of growth and puberty to the nuanced characteristics of metabolic syndrome, diabetes, liver pathology, carcinogenic potential, and cardiovascular disorders. A comprehensive literature review was conducted using PubMed, with a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method employing specific keywords related to child health, obesity, and insulin-like growth factors. This study reveals associations between insulin-like growth factor 1 and birth weight, early growth, and adiposity. Moreover, insulin-like growth factors play a pivotal role in regulating bone development and height during childhood, with potential implications for puberty onset. This research uncovers insulin-like growth factor 1 and insulin-like growth factor 2 as potential biomarkers and therapeutic targets for metabolic dysfunction-associated liver disease and hepatocellular carcinoma, and it also highlights the association between insulin-like growth factors (IGFs) and cancer. Additionally, this research explores the impact of insulin-like growth factors on cardiovascular health, noting their role in cardiomyocyte hypertrophy. Insulin-like growth factors play vital roles in human physiology, influencing growth and development from fetal stages to adulthood. The impact of maternal obesity on children's IGF levels is complex, influencing growth and carrying potential metabolic consequences. Imbalances in IGF levels are linked to a range of health conditions (e.g., insulin resistance, glucose intolerance, metabolic syndrome, and diabetes), prompting researchers to seek novel therapies and preventive strategies, offering challenges and opportunities in healthcare.
Keyphrases
- type diabetes
- insulin resistance
- growth hormone
- metabolic syndrome
- glycemic control
- healthcare
- birth weight
- weight gain
- high fat diet induced
- meta analyses
- high fat diet
- binding protein
- weight loss
- blood glucose
- systematic review
- pi k akt
- young adults
- public health
- cardiovascular disease
- adipose tissue
- skeletal muscle
- mental health
- uric acid
- polycystic ovary syndrome
- human health
- body mass index
- gestational age
- endothelial cells
- early life
- cardiovascular risk factors
- bone mineral density
- health information
- risk assessment
- angiotensin ii
- climate change
- pregnant women
- childhood cancer
- emergency department
- induced pluripotent stem cells
- adverse drug
- signaling pathway
- polycyclic aromatic hydrocarbons