Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.

Julián Benito-LeónAna Belén Del PinoYolanda AladroConstanza CuevasAngela Domingo-SantosVictoria Galán Sánchez-SecoAndrés Labiano-FontcubertaAna Gómez-LópezPaula Salgado-CámaraLucienne Costa-FrossardEnrique MonrealSusana Sainz de la MazaJordi A Matias-GuiuJorge Matías-GuiuAlfonso Delgado-ÁlvarezPaloma Montero-EscribanoMaría Luisa Martínez-GinésYolanda HiguerasLucía Ayuso-PeraltaNorberto MalpicaHelena Melero

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)

RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an "incidental finding" but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.

Keyphrases

resting state
functional connectivity
multiple sclerosis
neural network
end stage renal disease
newly diagnosed
ejection fraction
bipolar disorder
peritoneal dialysis
prognostic factors
subarachnoid hemorrhage