Programmed death ligand 1 (PD-L1) in colon cancer and its interaction with budding and tumor-infiltrating lymphocytes (TILs) as tumor-host antagonists.

Corinna Lang-SchwarzBalint MelcherArndt HartmannSimone BertzTheresa DregeliesKlaus Lang-SchwarzMichael ViethWilliam Sterlacci

Published in: International journal of colorectal disease (2021)

Overall, PD-L1 positivity correlated with markers of good prognosis. PD-L1 immunohistochemistry was able to identify parameters as additional potential candidates for immune therapy. Furthermore, it was able to stratify patients within the low budding/high TIL group with significant prognostic impact.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
stem cells
mesenchymal stem cells
patient reported outcomes
smoking cessation