Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis.

Ying Tang Mengchun ZhouRongrong HuangLing ShenLi YangZhongqiu ZhouHui RenYing Bai

Published in: Cell & bioscience (2021)

Overall, our present findings suggest that HECTD1 participates in LPS-induced astrocyte activation by activation of σ-1R-JNK/p38-FOXJ2 pathway and provide a potential therapeutic strategy for neuroinflammation induced by LPS or any other neuroinflammatory disorders.

Keyphrases

lps induced
inflammatory response
lipopolysaccharide induced
signaling pathway
cell death
induced apoptosis
traumatic brain injury
anti inflammatory