Metal-Organic-Framework-Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy.
Xueting PanLixin BaiHui WangQingyuan WuHongyu WangShuang LiuBolong XuXinghua ShiHuiyu LiuPublished in: Advanced materials (Deerfield Beach, Fla.) (2018)
Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal-organic-framework (MOF)-derived carbon nanostructure that contains porphyrin-like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle-assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high-speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure-dependent SDT enhancement of a MOF-derived carbon nanostructure.
Keyphrases
- metal organic framework
- reactive oxygen species
- high speed
- cell death
- healthcare
- magnetic resonance imaging
- atomic force microscopy
- risk assessment
- single molecule
- stem cells
- photodynamic therapy
- machine learning
- mesenchymal stem cells
- molecular dynamics
- convolutional neural network
- human health
- quantum dots
- electron transfer
- single cell
- clinical evaluation