Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain Injury.
Dicle KarakayaCanan Cakir-AktasSennur UzunFigen SoylemezogluMelike MutPublished in: Neurocritical care (2021)
In the mice head trauma model, different doses of Dex attenuate neuroinflammation by suppressing distinct components of the neuroinflammatory process in a different timecourse that contributes to neurologic recovery. These results suggest that Dex may be an appropriate choice for sedation and analgesia in patients with TBI.
Keyphrases
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- cerebral ischemia
- pain management
- high fat diet induced
- inflammatory response
- severe traumatic brain injury
- cardiac surgery
- smoking cessation
- ultrasound guided
- mechanical ventilation
- optic nerve
- trauma patients
- blood brain barrier
- metabolic syndrome
- type diabetes
- postoperative pain
- decision making
- wild type