Login / Signup

Single-Atom Fe-Catalyzed Acceptorless Dehydrogenative Coupling to Quinolines.

Yanze LuMeiling ZhuSanxia ChenJiewen YaoTing LiXu WangConghui Tang
Published in: Journal of the American Chemical Society (2024)
A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and nanocatalyst systems. Detailed characterizations, including aberration-corrected HAADF-STEM, XANES, and EXAFS, jointly confirmed the presence of atomically dispersed iron centers. Various functionalized quinolines were efficiently synthesized from different amino alcohols and a range of ketones or alcohols. The iron single-atom catalyst achieved a turnover number (TON) of up to 10 5 , far exceeding the results of current homogeneous and nanocatalyst systems. Detailed mechanistic studies verified the significance of single-atom Fe sites in the dehydrogenation process.
Keyphrases
  • room temperature
  • molecular dynamics
  • electron transfer
  • metal organic framework
  • ionic liquid
  • iron deficiency
  • molecular docking
  • postmenopausal women
  • molecular dynamics simulations
  • oxide nanoparticles
  • case control