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Radiation modulates expression and related activities of c-Met protein in oral tongue squamous cell carcinoma cell lines.

Aisha A H Al-JamaeiJan G A M de VisscherTymour ForouzanfarRuud H BrakenhoffC René LeemansArwen StikvoortBehrouz Zandieh-DoulabiMarco N Helder
Published in: Journal of cancer research and clinical oncology (2022)
These results provide novel insights into both intracellular and extracellular dynamics of c-Met expression profiles upon irradiation of OTSCC cells in vitro. It might also suggest that radiation enhances cell migration, indicative of invasiveness, through c-Met up-regulation, at least for certain types of OTSCC cells.
Keyphrases
  • induced apoptosis
  • cell migration
  • squamous cell carcinoma
  • cell cycle arrest
  • tyrosine kinase
  • radiation induced
  • endoplasmic reticulum stress
  • oxidative stress
  • binding protein
  • radiation therapy