B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus.

Anna HedenstedtSarah ReidAhmed SayadiMaija-Leena ElorantaElisabeth SkoglundKarin BolinMartina FrodlundKaroline LerangAndreas JönsenSolbritt Rantapää-DahlqvistAnders A BengtssonAnna RudinØyvind MolbergChristopher Sjöwall Johanna K Sandling Dag Leonard

Published in: Lupus science & medicine (2023)

High genetic burden related to B cell function is associated with dsDNA antibody development and LN. Assessing B cell PRSs may be important in order to determine immunological pathways influencing SLE and to predict clinical phenotype.

Keyphrases

systemic lupus erythematosus
genome wide
disease activity
copy number
risk factors
rheumatoid arthritis
gene expression
dna methylation
drug induced