Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood.

Patricia RiveraMaría T Ramírez-LópezAntonio VargasJuan DecaraMariam VázquezRocío ArcoRaquel Gómez de HerasJesús ArgenteFernando Rodríguez de FonsecaJulie A ChowenJuan Suarez

Published in: Acta physiologica (Oxford, England) (2019)

Maternal exposure to a free-choice high-calorie low-protein diet induces a long-term feed efficacy associated with changes in leptin signaling through IRS-1 and AMPK dephosphorylation in the hypothalami of female offspring in adulthood.

Keyphrases

weight loss
high fat diet
physical activity
skeletal muscle
depressive symptoms
protein protein
amino acid
early life
pregnant women
binding protein
protein kinase
type diabetes
birth weight
decision making
insulin resistance
metabolic syndrome
small molecule
weight gain