Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.

David Martín-GálvezDenis Dunoyer de SegonzacMan Chun John MaAnne E KwitekDavid ThybertPaul Flicek

Published in: BMC genomics (2017)

Our results show that the use of functional regulatory conservation is a potentially effective approach to select strain-specific genomic regions associated with phenotypic differences among Lyon rats and could be extended to other systems.

Keyphrases

transcription factor
copy number
oxidative stress
genome wide
dna methylation