UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C.
Boming CuiGe YangHaiyan YanShuo WuKun WangHuiqiang WangYu-Huan LiPublished in: Journal of virology (2024)
K33/K48-linked ubiquitination, thereby inhibiting viral proliferation. Our findings advance the knowledge related to the roles of 2C in EV-A71 virulence and the ubiquitination pathway in the host restriction of EV-A71 infection.