Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a/SIRT1/p53 and apoptosis.
Hamed HeydariRafighe GhiasiGholamreza HamidianSaber GhaderpourRana KeyhanmaneshPublished in: Hormone molecular biology and clinical investigation (2021)
This study revealed that voluntary exercise improved spermatogenesis, in part by decreasing the testicular oxidative stress status, apoptosis through alteration in miR-34a/SIRT1/p53 pathway.
Keyphrases
- oxidative stress
- high fat diet
- cell proliferation
- long non coding rna
- ischemia reperfusion injury
- high intensity
- diabetic rats
- insulin resistance
- long noncoding rna
- adipose tissue
- dna damage
- induced apoptosis
- germ cell
- physical activity
- resistance training
- endoplasmic reticulum stress
- single cell
- cell cycle arrest
- cell death
- heat shock
- skeletal muscle
- signaling pathway