The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage.
Susan M SheaAmanda M StaudtKimberly A ThomasDouglas SchuererJames E MielkeDanielle FolkertsEthan LowderCallista MartinGrant V BochicchioPhilip C SpinellaPublished in: Transfusion (2020)
The use of LTOWB is independently associated with improved 24-hour and 28-day survival, and does not increase organ dysfunction at 72 hours. Use of LTOWB most impacted survival of patients with reduced clot firmness (MCF ≤60 mm). Collectively, these data support the clinical use and continued study of LTOWB for hemostatic resuscitation.