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Tenofovir-induced hypophosphatemic osteomalacia: how do bone mineral density, trabecular bone score and proximal hip geometry change with treatment?

Aneez JosephKripa Elizabeth CherianNitin KapoorThomas Vizhalil Paul
Published in: Endocrinology, diabetes & metabolism case reports (2023)
Tenofovir is a nucleotide reverse transcriptase inhibitor (NRTI) and is a major drug in the treatment of retroviral and hepatitis B infections. Tenofovir-related hypophosphatemic osteomalacia is related to proximal tubulopathy and is not an uncommon occurrence. Treatment mandates changing to a non-tenofovir-based regimen with supplementation of neutral phosphate and calcitriol. Treatment results in a significant improvement in bone mineral density, trabecular bone score and hip geometric parameters.
Keyphrases
  • bone mineral density
  • postmenopausal women
  • body composition
  • risk assessment
  • emergency department
  • antiretroviral therapy
  • oxidative stress
  • stress induced
  • bone regeneration