Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase-3β-mediated activation of autophagy.
Jianmei GaoLong LongFan XuLinying FengYuangui LiuJingshan ShiQi-Hai GongPublished in: British journal of pharmacology (2020)
These findings indicate that icariside II attenuates cerebral I/R-induced injury via interfering with PKG/GSK-3β/autophagy axis. This study raises the possibility that icariside II and other PDE 5 inhibitors maybe effective in the treatment ischaemia stroke.
Keyphrases
- signaling pathway
- cerebral ischemia
- cell death
- subarachnoid hemorrhage
- endoplasmic reticulum stress
- oxidative stress
- atrial fibrillation
- acute myocardial infarction
- diabetic rats
- pi k akt
- high glucose
- heart failure
- coronary artery disease
- tyrosine kinase
- left ventricular
- acute coronary syndrome
- endothelial cells
- combination therapy