Pediatric high-grade gliomas and the WHO CNS Tumor Classification-Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates.

Gerrit H GielenJoshua N BaughDannis G van VuurdenSophie E M Veldhuijzen van ZantenDarren HargraveMaura MassiminoVeronica BiassoniAndres Morales la MadridMichael KarremannMaria WieseUlrich ThomaleGeert O JanssensAndré O von BuerenThomas PerweinGunther NussbaumerEelco W HovingPitt NiehusmannMarco GessiRobert KwiecienSimon BaileyTorsten PietschFelipe AndreiuoloChristof M Kramm

Published in: Neuro-oncology advances (2022)

Within the WHO classification of pediatric brain tumors, such as pedHGG, rapid changes in molecular characterization have been introduced. This study highlights the ongoing need for cross talk between pathologist and oncologist to advance the classification of pedHGG subtypes and ensure biological relevance and clinical impact.

Keyphrases

high grade
machine learning
deep learning
low grade
palliative care
young adults
loop mediated isothermal amplification